Sex-related differences in aging rate are associated with sex chromosome system in amphibians

TitleSex-related differences in aging rate are associated with sex chromosome system in amphibians
Publication TypeJournal Article
Year of Publication2022
AuthorsCayuela, H, Lemaître, J-F, Léna, J-P, Ronget, V, Martínez-Solano, I, Muths, E, Pilliod, DS, Schmidt, BR, Sánchez-Montes, G, Gutiérrez-Rodríguez, J, Pyke, G, Grossenbacher, K, Lenzi, O, Bosch, J, Beard, KH, Woolbright, LL, Lambert, BA, Green, DM, Jreidini, N, Garwood, JM, Fisher, RN, Matthews, K, Dudgeon, D, Lau, A, Speybroeck, J, Homan, R, Jehle, R, Başkale, E, Mori, E, Arntzen, JW, Joly, P, Stiles, RM, Lannoo, MJ, Maerz, JC, Lowe, WH, Valenzuela-Sánchez, A, Christiansen, DG, Angelini, C, Thirion, J-M, Merilä, J, Colli, GR, Vasconcellos, MM, Boas, TCV, Arantes, Ída C, Levionnois, P, Reinke, BA, Vieira, C, Marais, GAB, Gaillard, J-M, Miller, DAW
Pagination346 - 356
Date Published2022///
ISBN Number1558-5646
KeywordsAging, amphibians, LTER-HBR, senescence, sex chromosome

Sex-related differences in mortality are widespread in the animal kingdom. Although studies have shown that sex determination systems might drive lifespan evolution, sex chromosome influence on aging rates have not been investigated so far, likely due to an apparent lack of demographic data from clades including both XY (with heterogametic males) and ZW (heterogametic females) systems. Taking advantage of a unique collection of capture–recapture datasets in amphibians, a vertebrate group where XY and ZW systems have repeatedly evolved over the past 200 million years, we examined whether sex heterogamy can predict sex differences in aging rates and lifespans. We showed that the strength and direction of sex differences in aging rates (and not lifespan) differ between XY and ZW systems. Sex-specific variation in aging rates was moderate within each system, but aging rates tended to be consistently higher in the heterogametic sex. This led to small but detectable effects of sex chromosome system on sex differences in aging rates in our models. Although preliminary, our results suggest that exposed recessive deleterious mutations on the X/Z chromosome (the “unguarded X/Z effect”) or repeat-rich Y/W chromosome (the “toxic Y/W effect”) could accelerate aging in the heterogametic sex in some vertebrate clades.